Molecular Discovery Intelligence

Target: DPP4 Goal: Inhibition potency Activity measure: IC50 Evidence confidence: Any Policy: L2-DPP4-v1 Evidence snapshot: ChEMBL_37

#	Molecule	Potency	Evidence confidence	Selectivity	Commercial	Why
1	Chembl77538 ABZ-MOL-00030331	IC50 22.000000 nM Potency band (L2-DPP4-v1): >10-100 nM n=5 exact	Strong 5 pts · 5 assay · 3 doc · consistent · metadata 100%	Not evaluated — insufficient cross-target evidence	SOURCE	Why am I seeing this? #1 for DPP-4 inhibition potency measured by IC50 under L2-DPP4-v1. Median IC50 22.000000 nM (>10-100 nM) from 5 exact qualifying measurement(s) (range 7.000000-22.000000 nM). Evidence confidence Strong: 5 exact datapoints, 5 assay(s), 3 document(s), consistency consistent, metadata completeness 100%. 0 approximate and 0 censored measurement(s) shown but not ranked. Selectivity not evaluated (insufficient cross-target evidence). Commercial status is shown separately and is not part of this ranking.
2	Vildagliptin ABZ-MOL-00079329	IC50 34.000000 nM Potency band (L2-DPP4-v1): >10-100 nM n=1 exact	Limited 1 pts · 1 assay · 1 doc · not_evaluated · metadata 100%	Not evaluated — insufficient cross-target evidence	SOURCE	Why am I seeing this? #2 for DPP-4 inhibition potency measured by IC50 under L2-DPP4-v1. Median IC50 34.000000 nM (>10-100 nM) from 1 exact qualifying measurement(s) (range 34.000000-34.000000 nM). Evidence confidence Limited: 1 exact datapoints, 1 assay(s), 1 document(s), consistency not_evaluated, metadata completeness 100%. 0 approximate and 0 censored measurement(s) shown but not ranked. Selectivity not evaluated (insufficient cross-target evidence). Commercial status is shown separately and is not part of this ranking.
3	Chembl90558 ABZ-MOL-00017485	IC50 251200.000000 nM Potency band (L2-DPP4-v1): >10 uM n=1 exact	Limited 1 pts · 1 assay · 1 doc · not_evaluated · metadata 100%	Not evaluated — insufficient cross-target evidence	SOURCE	Why am I seeing this? #3 for DPP-4 inhibition potency measured by IC50 under L2-DPP4-v1. Median IC50 251200.000000 nM (>10 uM) from 1 exact qualifying measurement(s) (range 251200.000000-251200.000000 nM). Evidence confidence Limited: 1 exact datapoints, 1 assay(s), 1 document(s), consistency not_evaluated, metadata completeness 100%. 0 approximate and 0 censored measurement(s) shown but not ranked. Selectivity not evaluated (insufficient cross-target evidence). Commercial status is shown separately and is not part of this ranking.

Not ranked (evidence retained, shown)

Ranking is contextual to this objective and policy L2-DPP4-v1 — change the objective and the order may change. Ranking uses only exact (=) comparable IC50 measurements; approximate and censored values are retained and shown but never ranked. Commercial status is shown beside, never inside, the scientific score. Source facts from ChEMBL (EMBL-EBI); Abiozen-derived values flagged. No LLM.